Are there physicochemical differences between allosteric and competitive ligands?
نویسندگان
چکیده
منابع مشابه
Are there physicochemical differences between allosteric and competitive ligands?
Previous studies have compared the physicochemical properties of allosteric compounds to non-allosteric compounds. Those studies have found that allosteric compounds tend to be smaller, more rigid, more hydrophobic, and more drug-like than non-allosteric compounds. However, previous studies have not properly corrected for the fact that some protein targets have much more data than other systems...
متن کاملAre There Instructional Differences Between Fulltime and Parttime Faculty?
Using data from 8 academic departments and 361 courses taught during a semester, I examined differences between fulltime and parttime faculty in the areas of general demographic variables, student evaluation of teaching outcomes, and the distribution of grades earned. I expected fulltime faculty to exhibit higher teaching evaluations and less lenient grade distributions, yet neither hypothesis ...
متن کاملare there any differences between features of proteins expressed in malignant and benign breast cancers?
normal 0 false false false microsoftinternetexplorer4 background: the most common cancer among women is breast cancer and it has been blamed as the second leading cause of cancer death in women; so far many approaches have been used to analyze and detect benign and malignant forms of cancer and understanding the features involved in proteins expressed by various types of breast cancers is cruci...
متن کاملAre There Any Differences in Seismic Performance Evaluation Criteria for Concrete Arch Dams?
Differences between stress-based and strain-based criteria are investigated in seismic performance evaluation of the arch dams in time domain. A numerical model of the coupled dam-reservoir-foundation system is prepared with the finite element technique. Reservoir is modeled using the Eulerian approach as a compressible domain, and the foundation rock is assumed to be massless. Dynamic equilibr...
متن کاملNegative addiction to exercise: are there differences between genders?
INTRODUCTION Regular physical exercise has numerous benefits. However, there is a subset of the exercising population who may develop a compulsion to exercise excessively and who may, as a consequence, display physiological and psychological changes that have a direct influence on their quality of life. OBJECTIVE Our objective was to determine if there are differences between male and female ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2017
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1005813